Bioactive Small Molecules
Cayman Chemical ANTIBODY CZC-8004 5mg
An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES
Cayman Chemical Carflzomb 5mg
An irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM)
Cayman Chemical ANTIBODY ORY-1001 5mg
An LSD1 inhibitor (IC50 = 0.018 µM); selective for LSD1 over LSD2, MAO-A, and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM); inhibits the imidazoline I2 receptor, norepinephrine and dopamine transporters, and L-type voltage-gated calcium channels (IC50s = 0.37, 2.4, 1.7, and 4.9 µM, respectively); induces accumulation of H3K4me2 in THP-1 cells (EC50 = 0.0022 µM); reduces viability in a panel of primary AML cells at 100 nM; increases survival in a PDX mouse model of T-ALL at 0.0125 mg/kg
Cayman Chemical ANTIBODY Cu-ATSM 5mg
A copper-containing compound with diverse biological activities; inhibits ferroptotic cell death induced by RSL3, erastin, or iron(II) (EC50s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells at 1 µM; increases SOD1G37R protein levels, metalation, and activity in the spinal cord in the SOD1G37R transgenic mouse model of ALS at 30 mg/kg per day; increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model; versions containing positron-emitting copper isotopes have been used in PET imaging applications for selective labeling of hypoxic tissue
Cayman Chemical ANTIBODY OSI-027 5mg
An inhibitor of the catalytic site of mTOR, inhibiting both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively); prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 µM; effective in vivo
Cayman Chemical ANTIBODY SR-12813 10mg
A hypocholesterolemic compound that promotes the degradation of HMG-CoA reductase in various animal models; human and rabbit pregnane X receptor agonist (Kd = 41 nM; EC50 = 137 nM for hPXR in vitro) that can induce CYP3A expression in human and rabbit hepatocytes
Cayman Chemical ANTIBODY NK 252 25mg
A Nrf2 activator that interacts directly with the domain containing the Nrf2-binding site of Keap1; downregulates the expression of fibrogenic genes, producing antifibrotic effects in a rat model of non-alcoholic steatohepatitis
Cayman Chemical ANTIBODY DyphylIn 250mg
A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects; also inhibits mPGES-1 (IC50 = 200 µM) and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells
Cayman Chemical ANTIBODY CYM 5442 1mg
A selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM
Sigma Aldrich Fine Chemicals Biosciences 2-Deoxy-D-ribose BioReagent, suitable for cell culture | 533-67-5 | MFCD00135904 | 1G
2-Deoxy-D-ribose BioReagent, suitable for cell culture | Purity: >=99% (GC) | Mol Wt: 134.13 | 533-67-5 | MFCD00135904 | 1G
Sigma Aldrich Fine Chemicals Biosciences Trilostane >=98% (HPLC) | 13647-35-3 | MFCD00199295 | 10MG
Trilostane >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 329.43 | 13647-35-3 | MFCD00199295 | 10MG
Sigma Aldrich Fine Chemicals Biosciences Prunin >=95% (LC/MS-ELSD) | 529-55-5 | MFCD00210548 | 1MG
Prunin >=95% (LC/MS-ELSD) | Purity: >=95% (LC/MS-ELSD) | Mol Wt: 434.39 | 529-55-5 | MFCD00210548 | 1MG
Sigma Aldrich Fine Chemicals Biosciences Triptolide from Tripterygium wilfordii, >=98% (HPLC), solid | 38748-32-2 | MFCD00210565 | 5MG
Triptolide from Tripterygium wilfordii, >=98% (HPLC), solid | Purity: >=98% (HPLC) | Mol Wt: 360.4 | 38748-32-2 | MFCD00210565 | 5MG
Sigma Aldrich Fine Chemicals Biosciences Cyclophosphamide monohydrate | 6055-19-2 | MFCD00149395 | 5g
Cyclophosphamide monohydratePurity: | MW: 279.1 | 6055-19-2 | MFCD00149395 | 5g
Cayman Chemical ANTIBODY 2-D08 10mg
A synthetic flavone inhibitor of sumoylation; inhibits sumoylation completely in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM; inhibits sumoylation in breast cancer cell lines; disrupts the transfer of SUMO to the substrate; neuroprotective against Aβ aggregation and toxicity; has antioxidant properties